Interesting, does that mean that those Bitcoins are lost forever? Regular currency, coin and bills, are replaced at a steady pace. If Bitcoins are not replaced when lost, then it would be possible to lose all Bitcoins a some point, or am I wrong?
The idea is that there can only be 21 million Bitcoins, or something like that, but in the end there could be a lot less because they are lost.
Over a sufficiently large timescale, I think is an inevitable scenario. However, I have no idea whether that large timescale is measured in decades, centuries or millennia. If it's the latter, then it's probably not a huge problem.
Shish2k's point stands, only with "430 BTC is as many satoshis as there are US pennies".
But this is irrelevant anyway. If 1 satoshi ever becomes too coarse-grained, the whole Bitcoin community would obviously agree to revise the protocol to further subdivide satoshis...
The idea is that there can only be 21 million Bitcoins, or something like that, but in the end there could be a lot less because they are lost.