Every time I want to connect ADB to a device, it takes me far more time than it should. Having different ports for pairing and connecting is already a pain. I wonder what new hurdles will come up once they restrict adb to wlan0, even though atm I can't see any problems for my use cases (like pushing APKs, reading logs or connecting dev tools).

Not being able to use VPNs might be a problem in corporate setups (e.g. debugging an issue in production environments).