I don’t think there is remotely enough data on the subject to make any confident statements either way yet.
I think the only very confident thing I can say after watching and helping dozens of folks get started on these drugs is that everyone’s biology is vastly different.
I have friends who have lost close to a hundred pounds on the starting doses of their chosen GLP-1. I have other friends who barely lost anything after a year at max dose. Some of these people in both groups are highly motivated to lose weight and some are simply taking the drug as a magic fix and expending zero other effort into changing their lives. Some have very difficult mental issues and relationships with food, some have very few hangups on the subject.
I have never been able to predict with high confidence how any particular person is going to react to taking them. By and large the results are close to magical for the majority of folks, and there may be some correlation with folks who combine the drug with other lifestyle changes - but those are just general averages I see and certainly not scientific.
I think the only very confident thing I can say after watching and helping dozens of folks get started on these drugs is that everyone’s biology is vastly different.
I have friends who have lost close to a hundred pounds on the starting doses of their chosen GLP-1. I have other friends who barely lost anything after a year at max dose. Some of these people in both groups are highly motivated to lose weight and some are simply taking the drug as a magic fix and expending zero other effort into changing their lives. Some have very difficult mental issues and relationships with food, some have very few hangups on the subject.
I have never been able to predict with high confidence how any particular person is going to react to taking them. By and large the results are close to magical for the majority of folks, and there may be some correlation with folks who combine the drug with other lifestyle changes - but those are just general averages I see and certainly not scientific.