Self replicating automata as described by Von Neumann able to repair and duplicate themselves, and other things like electronic components. ICs keep getting faster (so far) but use smaller and smaller features of silicon and could wear out from metal migration and all components will be under much more cosmic radiation than on earth. This makes a large shield of heavy material on front of vehicle to minimize this effect but that increases the energy/fuel needed. The space shuttle only took maybe week long trips but it had four computers for flight control , three extra in case of failure in different parts of the shuttle along with IIRC a separate backup backup computer in for use as last resort.