The only time I was asked that question, I responded with "That's kind of a weird question, don't you think? I mean, it's not really in my interest to answer it honestly." The interviewer agreed, and we chatted about interviewing technique for a little while. He admitted that he only asked to see what people say, and that mine was probably the best answer he'd heard.
It's ironic that such a vapid and well-known question still reveals useful information about a candidate -- precisely because it is vapid and well-known.