One of the more non-obvious issues around pagination, especially with something like a webcomic where you're expecting to view multiple pages, is to have the page layout ensure that the buttons appear in the same place on each page.
This means that you can read the page, click 'next', and not have to move the mouse in order to progress onwards. Also annoying in slide decks and image slideshows.
Even better, just allow the user to navigate by hitting the left/right keys. The Atlantic's "In Focus" photo galleries do this, though all the images are on the same page in that case.
It's not always possible to place pagination links at the same location if the webcomic has images of different sizes, but I have yet to see a physical keyboard that moves around depending on what's on the screen.
Just don't bind to anything funny, like SMBC did, because it annoys the hell out of keyboard-based browsers users (like, try to copy URL to SMBC comic in Conkeror...).
Actually, I think a big one is missing: make next/previous redundant and put them side-by-side.
In other words, the layout should be like this:
Previous Next 1 2 3 4 . . . Previous Next
I hate accidentally clicking too far and then having to stop and figure out where the mouse should be to go back one page. Actions that are opposite should be side-by-side so that they can be undone quickly with minimal mouse movement.
Another good form of redundancy is to put all controls at the top of the page and all controls at the bottom. The top of the page is really good for keeping things in exactly the same place on every page, yet the bottom is often where people are after they're done reading.
Rule #0: Have proper pagination in the first place. Nobody likes it when they have to use "infinite scroll" to get to page 357. Especially if your site takes forever to load anything after the first few pages. (Yes, I'm talking to you, Twitter!)
"I'm In Like With You is a brand-new site that is best described as an online flirting site, or if you don't mind the term, a "Web 2.0 dating site". Think eBay + dating + Web 2.0 + social networks. "
Yeah, that's a very strange description as well. As far as I remember, it's always been about social gaming, and far before that was what it was even called.
One thing he misses is that a not insignificant number of webcomics will let you click on the comic to go to the next page. Biggest target you could ask for.
Sadly it's not a default on the very common Wordpress+Comicpress combo. Well it wasn't for a while, I just checked and there's a switch for it in my installation but I can't remember if it defaulted to on or off.
This means that you can read the page, click 'next', and not have to move the mouse in order to progress onwards. Also annoying in slide decks and image slideshows.