Long term damage to liver. You use it long enough your liver will die. But it's too hard to do a causal analysis on this as the timelines are measured in decades.
“However, the rate of true statin-induced hepatotoxicity is exceedingly low. Moreover, multiple retrospective studies have shown that statins are not only safe for use in patients with cirrhosis, but are also likely beneficial in reducing liver decompensation, hepatocellular carcinoma, infections, and death.”
