Yeah, it's very different; vaccinations are generally much deeper (into muscle), and drawing blood punctures a vein causing leakage into the surrounding tissue.
Daily injections can leave a little under-the-skin scarring (feels a little like cellulite) so you have to vary the site a bit, but for most folks that's the worst of it. Well worth it for these sorts of results.
Ah, my only experience is with things like vaccines and drawing blood; those marks last around a week on me.