Hacker News .hnnew | past | comments | ask | show | jobs | submitlogin

Vaccination also has more durable immunity than natural immunity in this case. Without those risks you outline.


I’m not sure this is clear. Yes, this is what has been stated in the media, but I have yet to see data to back the claim.

And in particular it has been shown that natural immunity produces a much broader set of antibodies that may allow the immune system to cope with variants better.

I’m not advocating natural immunity btw. I completely agree people should get the vaccine.


That’s actually incorrect. Someone was kind enough to cite in another reply to me.

I’m honestly a bit disturbed how much confidence software engineers have in their consumption of virology research. My good friend has worked in it for 10+ years not including a doctorate and worked on an mRNA vaccine.

I trust his takes more than any media and certainly more than some of these folks replying doubting the state of the science. Vaccines are the safest and best protection against COVID one can get.

Not specifically replying to you with that, just the general tone of these threads. Folks are out of their depth.


Hi Pot, meet Kettle?

My statement literally starts with "I'm not sure...". You begin yours with "That's actually incorrect." Which expresses more confidence?

My opinion is based on a conversation with a Ph.D immunologist that happens to be a friend as well. And if that's not enough here is a paper from a totally separate lab that has similar conclusions, with actual data https://www.biorxiv.org/content/10.1101/2021.07.29.454333v1

mRNA vaccines are obviously much better at generating antibodies for the RBD. That's an empirical fact, no one is disputing that. But natural immunity presents antibody targets beyond the RBD.


Just wanted to say thanks for the citation here, and FWIW all the literature I'm aware of supports the statements you've made in these comments.


You’re not aware of all of the literature, then. Vaccination results in fewer reinfections, less severe reinfections, and of course doesn’t require you risk a course of the virus upfront to get said protection.

Maybe reach out to an immunologist. There is a lot of literature and you shouldn’t trust my or anyone’s take, but expecting you’ll have a better take than several actual career immunologists based on some google scholar research is ill-founded.


If you finished the post, I mentioned I wasn’t referring to you.

With respect to the incorrect part, I was replying to:

“…it has been shown that natural immunity produces a much broader set of antibodies that may allow the immune system to cope with variants better.”

Which is indeed wrong.

Hope that helps


I expected this for the mRNA vaccine, but source?


> Now, a new NIH-supported study shows that the answer to this question will vary based on how an individual’s antibodies against SARS-CoV-2 were generated: over the course of a naturally acquired infection or from a COVID-19 vaccine. The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.

https://directorsblog.nih.gov/2021/06/22/how-immunity-genera...


* Citation needed.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: