But a Mac's interface is not an iOS interface. There are different constraints and different best practices, and sometimes completely different widgets. To make a decent UI, you have to understand the native platform.
I think the same argument can be made with regard to iPhone apps running on iPad. iPhone apps on the iPad are not very pleasant but if you absolutely must have that iPhone app on your iPad then you can put up with a suboptimal experience just to have the functionality.
I think the same thing occurs on the desktop. Many times I use iPad applications and wish they were available on the desktop. iPad applications especially I think can work very well on the desktop due to the large display.
But don't take my work for it. Have a look at the streamtome app on the mac app store. The interface mimics that of the iPad. I am not sure if it uses chameleon but there's a good chance I would guess.
