To me, this is an interesting result for three reasons:
1) it appears to be effective against three main forms of the Borrelia spirochete: the normal corkscrew shape, the round-body cyst, and biofilm (they don't call it by that name, but say "drug-tolerant persisters" whose meaning I'm inferring from rest of the literature).
2) it was approved to be tested in mice, which is a step on the way to human clinical trials. Other results, such as the active compound in honeybee venom, melittin, were only tested "ex vivo" on pigskin at body temperature.
3) it has the potential to work as quickly as antibiotics, and not 9 months to 2 years as many plant-based protocols take. Potentially without killing human gut flora.
There is anecdotal evidence of PTLDS patients who are skilled with phlebotomy being able to culture lyme bacteria from their blood samples after letting them sit for a day or two, something that no conventional blood lab has time to do.
Videos of spirochetes emerging from red blood cells (unverified by me), please excuse funky beats. This one is a little too horrifying for me to watch, as the bacteria is super creepy-looking.
https://howirecovered.com/lyme-disease-under-the-microscope/
Unfortunately, the lack of peer-reviewed results to verify this could mean either this method is not reliably reproducible, or there is no funding / appropriately prestigious or profitable way to pursue this line of research.
It's a question I'm interested in, and would help fund as a citizen scientist. Even without a proposed treatment, the methodology of reliably detecting Lyme borrelia in blood could itself be patented.
I'm very grateful this kind of research continues!
I think you missed the caption on the black and green picture:
> This image shows how the Lyme bacteria, Borrelia burgdorferi, form protective round body "persisters" when threatened by defensive immune system biochemicals in blood serum.
Re: #2
You don't need approvals to test in mice.
Re: #3
Antibiotics kill/greatly-diminish gut flora. Azlocillin is an antibiotic related to penicillin.
The other promising drug mentioned, disulfiram, is nothing to be trifled with, either:
1) it appears to be effective against three main forms of the Borrelia spirochete: the normal corkscrew shape, the round-body cyst, and biofilm (they don't call it by that name, but say "drug-tolerant persisters" whose meaning I'm inferring from rest of the literature).
2) it was approved to be tested in mice, which is a step on the way to human clinical trials. Other results, such as the active compound in honeybee venom, melittin, were only tested "ex vivo" on pigskin at body temperature.
3) it has the potential to work as quickly as antibiotics, and not 9 months to 2 years as many plant-based protocols take. Potentially without killing human gut flora.
There is anecdotal evidence of PTLDS patients who are skilled with phlebotomy being able to culture lyme bacteria from their blood samples after letting them sit for a day or two, something that no conventional blood lab has time to do.
Self-directed guide to blood microscopy to identify lyme borrelia (unverified by me): https://www.healingwell.com/community/default.aspx?f=30&m=37...
Videos of spirochetes emerging from red blood cells (unverified by me), please excuse funky beats. This one is a little too horrifying for me to watch, as the bacteria is super creepy-looking. https://howirecovered.com/lyme-disease-under-the-microscope/
Unfortunately, the lack of peer-reviewed results to verify this could mean either this method is not reliably reproducible, or there is no funding / appropriately prestigious or profitable way to pursue this line of research.
It's a question I'm interested in, and would help fund as a citizen scientist. Even without a proposed treatment, the methodology of reliably detecting Lyme borrelia in blood could itself be patented.
I'm very grateful this kind of research continues!