So full disclosure: I just started YC and we are only about 3 weeks into the program out of 12 weeks. So.... What I am about to say is without the full picture, but here's what I can say so far.
It's not too different than before :P. YC is very very hands off. I went to a pretty large public university and it sort of feels like that. There's a bunch of really awesome people, but there won't ever be anyone to hold your hand to make sure don't jump off a cliff. You or I need to seek out the right people and make sure to connect to those that would be best suited to help the business!
So, with all of that being said, I guess what I can say is that the experiences of being a solo founder are pretty identical to the experiences of being a solo founder in YC.
I'll elaborate more about some of the challenges I went through and some that I still do go through! But if I have bored you by now you can stop here hah.
I think as a solo founder you just go through different set of struggles, some easier and some more difficult than having multiple cofounders. At the end of the day we always just make the most out of our situation regardless of what that is (ie. don't force yourself to have cofounders or not have cofounders if the stars aren't aligned). To give you an idea of some of the struggles... I worked completely alone in my mom's garage for almost 2 years! I had a remote offshore team helping out with some of the work as we grew, but for a long long time it was just me. I actually hired my first in-house employee 2 weeks ago and he's been super awesome so far--what a game changer!
Anyways, going through this path was the first for a lot of things for me. I made a ton of mistakes that sometimes I wished I could've just bounced ideas off of someone else with from time to time. It was the first time I had ever programmed, so even getting my development setup took way longer than it should have, trying to market, sell a product, price a product, set up HR, design, legal, omg I am getting overwhelmed just thinking about at all of the stuff that I learned. But anyways, it was super rough at times just not knowing.... and having conversations with myself about whether or not I am making the right decisions. But the caveat to all of this was that I learned a tremendous amount in a short period of time and I made really quick decisions without ever feeling paralyzed by discussion. A lot of the time I made the wrong choice, but I learned! And for that... I am super grateful :)