Mice are used only partly because they share a considerable amount of DNA with us. But they're mostly used because they're cheap. Both in financial and ethical costs.
They live for about two years, and breed in about three months. They are disposable. Over 100 million are killed each year in various labs across the country.
And for all of this, only about 5% of medicine that show positive animal results make it to market in some fashion. So basically, the best thing we can say about a mouse-tested drug is that "this most likely won't make things worse". But that's like a low bar.
> And for all of this, only about 5% of medicine that show positive animal results make it to market in some fashion.
I'm surprised its that high tbh. And i suspect it would be a similar low number if we tested on humans instead of animals.
And yes, being able to test early stage ideas cheaply is critical to innovating. We use mice in biology for the same reason we use computer simulations in other fields.
Anyways, if we took your numbers of 5% chance at face value, that means there is a 1 in 20 chance of this press release turning into a real drug that saves real people's lives. Personally i dont think the chance is actually that high, but if it was that would only further my point that this is a milestone worth celebrating.
I think there's some kind of fallacy where you can look at five drugs, all of which came from a pool of 100 promising candidates, then look at the next 100 candidates and say for each one individually that it is not worth celebrating. I call it the, "rounding to zero" fallacy.
In reality, if you have 100 5% chances of a cure for a previously incurable illness, you can celebrate each chance a lot.
Which is why I found the Claude Super Bowl ads really weird.
They seemed like an indictment of the technology as a whole. The LLM character proxies all spoke with the LLM-cadence and phrasing. Because we all know it. LLM writing is very uncanny valley. And they didn't even try to deny this. It made LLMs itself look like a joke.
I think I understand why she told people not to look up her credits.
It seems this may be a case of "I am representative of everyone's experience."
Her first credit was in 2008 and then there is a 5 year gap between that and her next credit. Then 8 years between that one and the next.
For comparison, I pulled up the crew for The Boys. Most of them have tighter credits.
While there is probably some people in her situation. I feel that she also could have written this with the title: "I Work in Hollywood. Everyone Who Used to Make TV Is Now Waiting Tables."
And this isn't to disparage her. It was always a hard business and getting consistent work was always hard. Even if it is good.
I can talk to plumbers. I can talk to electricians, hvac, construction guys, anyone in the trades. Because what they work on are essentially systems and systems are interesting to me.
Trust me, these guys don't really mind talking shop. And they appreciate someone acknowledging that they do have knowledge and skill not everyone has.
We use a VPN to enable remote users to access our internal network for things we don't want exposed to the public at large. And we're not a tech company.
This really sounds like someone who has no fucking clue trying to legislate away all the loopholes to their other shitty legislation.
These are aspirational laws. They pass them to try to force innovative enforcement measures. Same thing with NJ and smart guns, NYC and 3D printing, TX abortion meds, etc.
Perhaps your CEO has less political capital than Meta’s.
Story goes they need proof of humanity for their business (advertising) survive. Pesky things like the continuity of businesses they don’t own, that can be figured out later.
How it works in Russia, if your corporate VPN is blocked by mistake, you can just submit the application to whitelist it, providing all the necessary documentation (we have pretty advanced e-government system so you can submit it online), and with high probability it would be accepted. If your VPN gets accidentally blocked again, all you need is to write to an on-duty officer and it will be unblocked.
Dont they just pass a bill saying you can use the state audited VPN as provided by SecUTAH for remote access. Submit your business requirements for review and oh we also know all the keys for anti terror reasons.
That was 1999. Invasion came out that year. Innistrad, Mirrodin, Ravnica, and other settings all came out after Hasbro's acquisition.
Every year seems to be the best-selling year so far. Magic: the Gathering is Hasbro's primary revenue source.
And look, I don't like the sheer amount of product they're pumping out every year now. But I realize I'm clearly in the minority opinion based on sales.
It's possible she believes that those items all trigger her migraines therefore her body gives her a migraine when she believes she's had one of her triggers.
A big tell would be her getting a migraine and blaming it on "hidden MSG" in a food item that doesn't have it.
Or her not getting migraine from foods that have MSG naturally but is never pointed out. Like tomatoes.
It's funny... reading this thread, I'm reminded of a friend of mine who indeed gets migraines from tomatoes. That was actually what she figured out first; the MSG connection came later.
Mice are used only partly because they share a considerable amount of DNA with us. But they're mostly used because they're cheap. Both in financial and ethical costs.
They live for about two years, and breed in about three months. They are disposable. Over 100 million are killed each year in various labs across the country.
And for all of this, only about 5% of medicine that show positive animal results make it to market in some fashion. So basically, the best thing we can say about a mouse-tested drug is that "this most likely won't make things worse". But that's like a low bar.
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