I used to write 10-20kloc projects in javascript. Don't know if its large enough for you but i dont feel any problem to maintain large js applictions written by good programmers. Try CoffeeScript anyway.
BTW "jQuery programmer" sounds obnoxiously we are javascript programmers.
I can run multiple instances in parallel fullspeed on a shitty mac. If you don't have a GPU (or a blacklisted one), expect your browsers to run like shit.