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The folks at Arc are trying to build this! https://arcinstitute.org/news/virtual-cell-model-state


STATE is not a simulation. It's a trained graphical model that does property prediction as a result of a perturbation. There is no physical model of a cell.

Personally, I think arc's approach is more likely to produce usable scientific results in a reasonable amount of time. You would have to make a very coarse model of the cell to get any reasonable amount of sampling and you would probably spend huge amounts of time computing things which are not relevant to the properties you care amount. An embedding and graphical model seems well-suited to problems like this, as long as the underlying data is representative and comprehensive.


This seems pretty serious, but I wonder if there is a way to measure how many systems are affected by this. Does anyone have telemetry on how many Runas configs are set up this way? How would someone collect this data?


In my experience not many people are aware of the permission model of sudo and I expect a lot of users are merely granted root access. At the same time those deployments which do use sudo's permission model are likely high cost.


Is it just me or did the OP just reinvent Weight Watchers points?


Yes, and he describes it as his “lightbulb moment”.



Marty Chavez was, but got promoted:

> Prior to assuming his current role, Mr. Chavez was Chief Information Officer, responsible for the Technology Division

Profile on him from a few years back: https://www.nytimes.com/2016/04/03/business/dealbook/goldman...


Well, that's something at least. They have a CIO. And someone with a tech background can make it to the inner circle. Still, the CIO is not counted among the top executives.


Why are you assuming that someone with the title "CIO" has a tech background?

I worked at a place where the CIO was a lawyer who knew the business really well, but no real tech in his background.


Because it is in accord with my experience and my general sense that people should know what they are doing in the areas they are are given responsibility over. That generally requires experience, and at high level probably extensive experience. It's hard to see how a lawyer with no real tech experience can make good choices in the area of technology.


He wasn't great but he wasn't terrible. He had a very logical mind and tried to choose wisely as far as whose advice he took.

His only knock was that he believed the Cyber Security FUD too much.

Other than that, solid guy and I'd work for him avain.


> Some jobs simply carry with them the understanding you are going to be "used up" by participating. Wrestlers, boxers, hockey players, and now footballers. Some men are willing to destroy themselves in pursuit of wealth and fame, and it's difficult to say it's our job as a society to overrule their choices about their own bodies.

I think one of the more interesting comparisons starts when you look past professions that promise fame and fortune, and start looking at jobs like firefighting, police work, and military service. I would argue that there is a similar progression of personnel (as evidenced by earlier retirement and pension ages for these professions) but the pot of gold at the end of rainbow is less celebrity and more a consistent job and service to one's community. Where do those professions stand on the spectrum?


For those who wanted a look at which decks raised large amounts of money, the two you're concerned with are

WeWork (355mm series D): https://attach.io/startup-pitch-decks/#wework

and

Mixpanel (65mm Series B): https://attach.io/startup-pitch-decks/#mixpanel


Our sincerest apologies that things slipped through. We were able to identify you based on the description above, and I'll personally follow up in hopes of making amends.

Last month was our first time posting in the HN Hiring thread, and we didn't know how much volume we'd get. We responded in a very ad-hoc fashion, without implementing enough process around it. After some promising candidates came through the HN pipeline last month, we built out a bit more process for this month -- your feedback is very valuable and we'll do our best to prevent similar failure modes from happening again for other candidates.


I just wanted to add that Andrew did reach out and offer an apology over the mistake in their process. As I told him, I think this speaks very highly of Predata. Very few companies would be willing to do such a human gesture. It sounds like they have the hiring management sorted out now and you can all effectively disregard my earlier comment. I am glad to hear it.


Given the microUSB ports in the third and fourth images, I'd say it's likely.


Not a single mention for Battleship, the game that (I would warrant) introduced most current American 20-somethings to the concept?


I think you're probably right about the concept, but I didn't know that it was "a thing" until the documentary The Fog of War[1]. Excellent retrospective about Vietnam.

[1]: https://en.wikipedia.org/wiki/The_Fog_of_War


Wargamers tend to have narrow elitist focus when it comes to boardgaming. I think its because they see their hobby as more than simply playing a childrens game for the fun of it, rather they see it as a more serious exploration of history. Since it has a war theme, I agree with you that Battleship completely revolves around FOW.. Stratego is another example of a classic boardgame that does this as well. Neither one of those games touch on "friendly" FOW mentioned in the article though. If you want to try a lighter game that implements "friendly" FOW give Memoir 44 a spin. Hidden information is also a standard feature of many games that don't have anything to do with war...poker for example.


Is that the old paper game where you place shots on grid references to sink your opponent's ships? Or something else?


Milton Bradley made a very popular mass-market version of the paper game using a plastic gameboard and ships that has been a longtime bestseller: https://boardgamegeek.com/boardgame/2425/battleship


OK it is the game I'm thinking of. I remember the set too. Never thought of it as modeling fog of war before, though.


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